I think the easiest way is 290 to 395.  

Take rt. 82 Norwich exit.  Take a right onto 82.  

It is quite a way on 82, at your second 4 way stop (just past Lyme Fire Dept.) 
at blinking light turn right (still on 82) and we are just over a mile on right.  

Gray house with red doors, #96.  

860-873-9856